Ineffective erythropoiesis of TET2 deficiency
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چکیده
منابع مشابه
Ineffective Erythropoiesis in β-Thalassemia
In humans, β -thalassemia dyserythropoiesis is characterized by expansion of early erythroid precursors and erythroid progenitors and then ineffective erythropoiesis. This ineffective erythropoiesis is defined as a suboptimal production of mature erythrocytes originating from a proliferating pool of immature erythroblasts. It is characterized by (1) accelerated erythroid differentiation, (2) ma...
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BACKGROUND SF3B1 is a core component of splicing machinery. Mutations in SF3B1 are frequently found in myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ringed sideroblasts (RARS), characterized by isolated anemia. SF3B1 mutations have been implicated in the pathophysiology of RARS; however, the physiological function of SF3B1 in erythropoiesis remains unknow...
متن کاملCarbon monoxide production associated with ineffective erythropoiesis.
The rate of endogenous carbon monoxide production ( Vco), determined by the closed rebreathing system technique, was elevated above the normal range in four of five patients studied with ineffective erythropoiesis (four patients with primary refractory anemia, one with thalassemia). The mean molar ratio of Vco to Vheme (rate of circulating heme catabolism, determined from (51)Cr red cell surviv...
متن کاملIncreased formation of early-labeled bilirubin in rats with iron deficiency anemia: evidence for ineffective erythropoiesis.
I RON DEFICIENCY ANEMIA is usually characterized by erythroid hyperplasia of the bone marrow, but impaired net synthesis of hemoglobin. This association suggests that the anemia may be due in part to ineffective erythropoiesis, i.e., destruction of immature red cells in the bone marrow or soon after their release into the circulation. Morphologic observations are also compatible with ineffectiv...
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The importance of inadequate haemoglobin synthesis and ineffective erythropoiesis in the anaemia of rheumatoid arthritis was studied by measuring the incorporation of 15N glycine into haemoglobin haem and early labelled bilirubin in a patient with severe anaemia before and after response to gold therapy. Initially, total erythroid haem turnover was decreased but haem turnover due to ineffective...
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-10-878645